CKD Stage 3 Symptoms

When other medications do not take effect, you can try cyclosporine A for proteinuria. It may help you reverse your kidney disease.

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Cyclosporine A for Proteinuria

2018-12-27 10:22

Cyclosporine A for ProteinuriaModerate or above proteinuria can cause progressive decline in kidney function, and it is necessary to call for the support of strong drugs, which refer to immunosuppressants, such as glucocorticoids (prednisone, methylprednisolone, cortisone), cyclophosphamide, lefluromide, mortefacolamate mofetil, tacrolimus and so on.

These drugs have the function of lowering proteinuria and preventing the deterioration of kidney function. Some of them are first-line drugs or first-choice drugs, such as prednisone and cyclophosphamide.

However, the immunosuppressant we are going to introduce today is not the first-line drug, but the "bottom card" of the protein-lowering drugs -- cyclosporine A (CyA).

The reason why it's called bottom card is that cyclosporine A is often used when other drugs don't work and it can improve some kidney diseases that is not treatable. Originally widely used in organ transplantation and immune diseases, it has been widely used to treat refractory Nephrotic Syndrome and other kidney diseases in recent years.

CyA can be used into various kidney diseases, such as

1. Minimal Change Disease

2. Membranous Nephropathy

3. Focal Segmental Glomerulosclerosis (FSGS)

4. IgA Nephropathy

5. Mesangial Proliferative Nephritis

6. Lupus Nephritis

Precautions for taking cyclosporine:

As the bottom card in the strong drugs, it should be paid special attention during medication.

1. Dosage

Cyclosporine is nephrotoxic, but is generally safe at doses below 5 mg/kg. Start with a small dose until the blood concentration is stable.

In addition to nephrotoxicity, side effects of cyclosporine include hypertension, metabolic abnormalities, infection, thrombotic microangiopathy, gingival hyperplasia and gastrointestinal reactions.

2. Monitor drug concentration in the blood and kidney function

Discontinuation of cyclosporine is required if renal function is found to decline without any other inducement other than cyclosporine. When checking the blood concentration of cyclosporine, the blood should be drawn on an empty stomach before taking the medicine in the morning, and the blood drawn after taking the medicine will interfere with the blood concentration test results.

3. Time to take medicine

The blood concentration of cyclosporine is affected by food metabolism, so it should be taken 2 hours after meals or 1 hour before meals. And take the medicine twice a day, at intervals of as little as 12 hours.

4. Contraindication

This product is not allowed for viral infection: such as chicken pox, herpes zoster, etc.

Cyclosporine cannot be used in patients with stage 4-5 CKD (glomerular filtration rate lower than 30ml/min, creatinine higher than 443 microns /L).

Conclusion

When we use immunosuppressants, we usually use hormones for minimal change disease, methylprednisolone every other month + cyclophosphamide + oral prednisolone every other day for membranous nephropathy and so on. And most of the time we don't think about cyclosporine first.

But when these options don't work, or are inconvenient to use for other reasons, don't forget that cyclosporine can be used to treat patients who are partially ineffective with conventional treatment. For more information on proteinuria treatment, please leave a message below or contact online doctor.

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