As is know to all kidney works as a filter in our body. Kidney contains millions of nephron which is made up of glomerulus, kidney tubule and renal corpuscle. Normally, blood flows through glomeruli which will filter metabolic waste into urine. If the blood pressure goes up in a short period, glomerulus could keep blood pressures and filtration rate stable by the regulation of inferent and efferent arteriole.
If blood pressure keeps at a high level, the regulation will be disturbed. Thus, the blood pressure in glomeruli is abnormally high. Persistent high blood pressure will strain the blood vessels. Under long-time strain, glomeruli will be damaged and symptoms occur, such as protein leakage and inflammation.
Proteinurine aggravates the kidney damage, and inflammation will cause vessels get narrow, which is a vicious circle exacerbating the illness. Healthy kidney has the function of regulating blood pressure. If blood pressure drops, the kidneys are able to release rennin into the body that causes blood pressure to rise to stable levels. Rennin is a part of the renin-angiotensin-aldosterone system. If there is a low blood pressure, kidney will release rennin, which is a trigger for angiotensin. Angiotensin is used to narrow the blood vessels and blood pressure will goes up. With the disease progress, the damaged kidney will lose more function, like regulating blood pressure and keep acid-base balance. Symptoms of Hypertensive Nephropathy will occur to patients.
It is important to note that chronic high blood pressure damages kidney, and, in turn, damaged kidney is unable to regulate blood pressure. Therefore, treatment for hypertensive nephropathy should control the blood pressure and restore kidney function meanwhile. What’s more, having a better understand of the causes of the disease help patients comply with treatment.