IgA Nephropathy

In this column, IgA Nephropathy patients can get comprehensive information about their disease: symptoms, treatment, life expectancy and prognosis, basics, diagnosis and diet.

Kidney Treatment Group Invite Links

Kidney Treatment Group Invite Links.We have doctors to answer you. Besides, we will provide you some information about diet and treatment regularly to help you fight against kidney disease.

IgA Nephropathy Causes, Symptoms, Treatment and Diet

What causes IgA Nephropathy?

IgA Nephropathy (or Berger's Disease) is an autoimmune disorder which causes IgA immune complexes depositing and trapping in glomerular mesangial area.

These deposits cause inflammation of glomerulus and proliferation of mesangial matrix cells, and eventual scarring of the glomerulus. Glomeruli are the filters of kidney. Once blood can not flow through the lumen of glomeruli, glomeruli become non-functional. The kidney function declines gradually. The kidneys may show signs of damage, after 10 to 20 years with IgA Nephropathy. But some IgA Nephropathy patients have a rapid-progress, leading to ESRD within 5 years or less. About 25 percent of adults with IgA Nephropathy develop into complete kidney failure. Only 5 to 10 percent of children develop total kidney failure.

Back top

What’re symptoms of IgA Nephropathy?

In the early stages, IgA Nephropathy has no symptom. IgA Nephropathy patients may live with the disease without realizing it. The disease can be detected by blood in the urine, sometimes accompanied protein in the urine. These symptoms may occur after a cold, sore throat, or other infections. If small amount blood is in the urine, it can only be detected by a doctor or nurse using special tests. If the amount of blood increases, urine may turn pink or the color of tea or cola. IgA Nephropathy also causes symptoms, like edema, high blood pressure, tiredness and itchy skin.

However, hematuria doesn’t mean patients with IgA Nephropathy. Other cases, like heavy exercise, also can lead to hematuria.

Back top

How is IgA Nephropathy diagnosed?

If blood presents in the urine, urine needs to be examined by microscope to find whether the kidney filter is damaged. Ultrasound of the kidney and cystoscopy could find the source of bleeding. The two tests would rule out kidney stones and bladder cancer. Tests of creatinine and blood urea nitrogen (BUN) could examine whether the kidney work normally.

If there is a severe kidney damage, a kidney biopsy is recommended. Result of the biopsy could tell us whether there are IgA deposits in glomeruli and the degree of kidney damage. Once a diagnosis of IgA Nephropathy is established, a person should have regular blood tests to monitor kidney function. Patients with severe kidney damage should receive treatment to preserve their kidney function.

Back top

How to treat IgA Nephropathy?

Though we still don’t find the cure of IgA Nephropathy, efforts can be made to slow the progress of kidney damage, such as limiting the amount of protein in diet and careful control of high blood pressure. There are some medicines and therapy recommended to IgA Nephropathy patients:

ACEI and ARB: These medicines could control the blood pressure, which a common complication of IgA Nephropathy. The two medicine also has the effect of alleviate proteinuria.

Omega-3 fatty acids: These beneficial fats, available in dietary fish oil supplements, may reduce inflammation in the glomeruli.

Corticosteroid medications: Prednisone and other potent drugs can suppress the immune response, so that prevent further damage in the glomeruli. However, these drugs can cause a range of serious side effects, such as high blood pressure or high blood sugar, so their benefits must be carefully weighed against the risks.

Micro-Chinese Medicine Osmotherapy: Besides these western medicines, Micro-Chinese Medicine Osmotherapy, which is based on traditional Chinese medicines also have effective efficacy with the disease. This Osmotherapy has the effects of anti-inflammation, degradation of IgA-deposition and vessel dilation. The first two effects could get the patients’ conditions in control. After dilating vessels, kidney could get more oxygen and nutrients for recovery.

Back top

In summary

We hope that these information could help you make better choice in your treatment. However, before you make any changes in you supplements or medications, consult you doctor. If you still have anything unclear or need any help, you can contact us for free.